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Transform your weight loss journey with clinically-proven weight loss injections.
It’s hard to know where to start with your weight loss journey. That’s why our team is here to help you find the right treatment for your lifestyle.
Our injectable weight loss treatments are scientifically proven to help you lose weight when paired with an active lifestyle and balanced diet, working alongside your body and not against it.
Browse our MHRA-approved medications, trusted by 30,000+ weight loss patients with 29,000 5-star Trustpilot ratings.
Looking for weight loss tablets? Find our range of tablets and capsules here.
Our range of effective weight loss injections put you in control of your weight loss journey.
Easy to administer at home, these weekly injections are designed for long-term weight loss management.
Mounjaro | Wegovy | |
|---|---|---|
Active ingredient | Tirzepatide - dual GIP and GLP-1 receptor agonist | Semaglutide - GLP-1 receptor agonist |
How does it work? | Suppress appetite and makes you feel fuller for longer | Suppress appetite and makes you feel fuller for longer |
How do I take it? | Weekly injection | Weekly injection |
Dosing | 6 different strengths, gradually increased every 4 weeks. | 6 different strengths (up to 2.4mg), gradually increased every 4 weeks. 7.2mg available if needed. |
Expected weight loss | On average 20-22.5% of starting body weight (15mg) at SURMOUNT-1 trial. (1) | On average 15-17% of starting body weight (2.4mg). On average 19-21% of mean loss at 7.2mg in STEP UP trial. (4) |
Prescription required? | Yes | Yes |
Additional benefits | Because of their successful weight loss journey, patients may find they experience a better quality of life, better movement and body image. | Wegovy is licensed for the reduction of the risk of major adverse cardiovascular events. Because of their successful weight loss journey, patients may find they experience a better quality of life, better movement and body image. |
Because Mounjaro (Tirzepatide) and Wegovy (Semaglutide) are different active ingredients, they work slightly differently in the body — Trizepatide is a dual GIP and GLP-1 receptor agonist and Semaglutide is a singular GLP-1 agonist — however both have seen meaningful weight loss results.
Let’s look at the main ways weight loss medications work:
Appetite suppression
The active ingredients in Mounjaro and Wegovy can suppress your appetite resulting in you starting to feel less hungry. Many people report that their previous ‘food noise’ reduces significantly when using Mounjaro or Wegovy.
Feeling fuller for longer
By slowing down how long it can take food to pass through your system, the active ingredients in Mounjaro and Wegovy can help you feel fuller for longer, meaning you may feel more satisfied after eating.
It's important to remember that adopting a healthier diet and lifestyle will also play a key role in the success of your weight loss journey. Our expert team is with you at each step.
The active ingredients used in Mounjaro (Tirzepatide) and Wegovy (Semaglutide) have both shown consistent weight loss results in a number of clinical trials. Here are some key results:
Mounjaro weight loss results (SURMOUNT-1 trial)
People who reached the highest Mounjaro dose (15mg) lost on average 20-22.5% of their starting body weight over 72 weeks, and:
96% achieved 5% weight loss or more
90% achieved 10% or more
78% achieved 15% or more
Roughly 55% achieved 20% or more
Wegovy weight loss results (STEP UP Trial)
People who reached the highest Wegovy dose (7.2mg) lost on average 19-21% of their starting body weight over 72 weeks. Other results showed that:
90.7% achieved 5% weight loss or more
47.7% achieved 20% or more
31.2% achieved 25% or more
Weight loss injections (Mounjaro and Wegovy injections) have been shown to offer several health advantages beyond weight loss itself.
Cardiovascular benefits: Clinical trials have demonstrated that Semaglutide (Wegovy) can reduce the risk of major cardiovascular events such as heart attack and stroke in people with existing heart disease (6).
Joint pain relief: Treatment with Semaglutide (Wegovy) demonstrated a clinically meaningful improvement in knee osteoarthritis-related pain compared to the placebo (4)
Because of their successful weight loss journey, patients on both Mounjaro and Wegovy may find they experience a better quality of life, better movement and body image.
These health benefits are typically most significant when weight loss treatment is combined with a healthy diet and regular exercise.
Weight loss injections are prescription-only medications. It’s important to understand that all online weight loss consultations are clinically reviewed by independent doctors and completing a consultation doesn’t guarantee treatment.
Prescription weight loss treatments are typically eligible for:
Adults aged 18-85
Those with a BMI above 30 (or a BMI above 27 and a weight-related condition such as high blood pressure or cholesterol, etc.)
Individuals who don't have type 1 diabetes or being treated for type 2 diabetes with insulin or more than one anti-diabetic medicine.
This list is only intended as an indicator for who might be suitable for treatment. The doctors will complete a full medical review of your consultation to determine your individual suitability for treatment.
Certain conditions and medicines may make the use of weight loss injections not suitable and our prescribers will guide you as to whether it is safe to prescribe according to your medical history.
For menopausal women taking HRT, you should consider changing oral oestrogen to transdermal oestrogen and also increasing the dose of progesterone for 4 weeks after initiation of a GLP-1 or after any dose change. You should discuss this further with your GP or prescribing Doctor.
Our 3-step process makes ordering your weight loss treatment hassle-free and secure.
Complete a confidential online consultation and choose a preferred treatment
A doctor will review your consultation to make sure it’s right for you
If approved, we’ll dispense your treatment and send it via our tracked delivery service
Sometimes we may need to contact you to confirm a few details before making a treatment decision.
If you're thinking about switching from Mounjaro to Wegovy, take a look at our switching guide to see if it might be right for you.
Explore a range of helpful links to aid your weight loss journey.Â
Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, et al. Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine [Internet]. 2022 Jun 4;387(3):205–16. Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038. Retrieved May 7, 2026.
Aronne LJ, Sattar N, Horn DB, Bays HE, Wharton S, Lin WY, et al. Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial. JAMA [Internet]. 2023 Dec 11;331(1). Available from: https://jamanetwork.com/journals/jama/fullarticle/2812936. Retrieved May 7, 2026.
Wilding JPH, Batterham RL, Calanna S. Once-Weekly Semaglutide in Adults with Overweight or Obesity. The New England Journal of Medicine [Internet]. 2021 Feb 10;384(11):989–1002. Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa2032183. Retrieved May 7, 2026.
James D. STEP UP Trial Shows Semaglutide 7.2 mg Achieves Superior Weight Loss vs. 2.4 mg, Placebo [Internet]. Applied Clinical Trials. 2025. Available from: https://www.appliedclinicaltrialsonline.com/view/step-up-trial-semaglutide-superior-weight-loss. Retrieved May 7, 2026.
Ghusn W, De la Rosa A, Sacoto D, Cifuentes L, Campos A, Feris F, et al. Weight Loss Outcomes Associated With Semaglutide Treatment for Patients With Overweight or Obesity. JAMA Network Open [Internet]. 2022;5(9):e2231982. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486455/. Retrieved May 7, 2026.
Novo Nordisk Limited. Wegovy® (semaglutide) Summary of Product Characteristics. Available from: https://www.medicines.org.uk/emc [accessed 11 May 2026].
They are breakthrough weight loss options that have been scientifically designed to support long-term weight loss. Depending on the treatment you choose, they use a range of active ingredients (sometimes referred to Tirzepatide and Semaglutide) that stimulate naturally occurring hormonal receptors. This can help you feel fuller for longer, slow gastric emptying (how fast food travels through your system) and reduce cravings. It’s these action that can help you lose weight.
They are science-backed weight loss options that have been designed to support long-term weight loss. They’re an alternative option for people who don’t want to self-inject. Depending on the treatment you choose, they can work by inhibiting enzymes in your digestive tract. This reduces the amount of fat your body can absorb from your food. It’s this action that can help you lose weight.
Our range of treatments are generally considered safe to take alongside other medications, however interactions can happen and there are specific conditions and medications where weight loss treatments aren’t suitable to take. That’s why it’s important to give a full and honest answers in your online consultation.
We offer a range of weight loss treatments, some of which are prescription-only medications. Each treatment has its own eligibility options. As a guide, we’d ask you to check initial eligibility against the criteria below. Meeting this is not an indicator of treatment suitability and our doctors will fully review your completed online consultation.
Adults aged 18-75
Those with a BMI above 30 (or a BMI above 27 and a weight-related condition such as high blood pressure or cholesterol, etc.)
Individuals who don’t have diabetes or pre-diabetes requiring treatment
All online consultations are clinically reviewed by the doctor team. They review your answers to determine your suitability for your selected treatment. They are fully regulated in the UK and are approved to prescribe and dispense your treatment. Read more about our team.
Each treatment comes with its own risk of side effects. Most of these are mild, and if you do experience any, most ease off in a short period of time. However, you should always explore the full list of potential side effects in the Patient Information Leaflet which comes with your selected treatment.
Weight loss varies with each person and contributing factors can include their lifestyle, their mobility and which treatment they’ve selected.
Typical weight loss examples:
Mounjaro – up to 25% of your starting body weight
Wegovy – up to 20% of your starting body weight
Orlistat (Xenical) – more than 5% of your starting body weight
Mysimba – more than 5% of your starting body weight
The latest clinical guidance recommends taking a daily multivitamin to ensure you’re getting all that you need. There is a risk you might not be getting all the vitamins you need through food if you’re eating less or have changed your diet.
Whilst there isn’t a specific diet to follow, it’s recommended that you follow a healthy & balanced diet. Focus on creating balanced meals that contain adequate protein and fibre. Make sure to drink plenty of fluids too.
Aim for 3 meals a day, with snacks in between if needed, to provide your body with steady energy throughout the day. A balanced meal should look like:
Filling half your plate with non-starchy vegetables, salad or fruit.
Filling the other half evenly between wholegrain carbohydrates and lean protein
Include a small serving of healthy fats within your meal
When it’s time to reorder, simply log in to your secure online Oxford Online Pharmacy account and select the treatment you’d like to reorder. You will always need to complete a new consultation and upload new dated photos so that we can make sure your treatment is still right for you.
Reaching your goal weight is a significant achievement, but the decision about continuing weight loss medication should always be made with your prescriber. Many people benefit from staying on a lower, maintenance dose to help sustain their weight loss, as obesity is a chronic condition that often requires ongoing management. Your prescriber will consider factors such as how well you've maintained healthy lifestyle habits, your individual health needs, and whether you're at risk of weight regain. If you do stop treatment, it's important to have a plan in place with continued support for diet, exercise and behavioural changes to help maintain your results.
A maintenance phase refers to the period after you've achieved significant weight loss, where the focus shifts from losing weight to keeping it off. During this phase, you may continue taking your medication at the same dose, or your prescriber might adjust it to a lower maintenance dose. The goal is to prevent weight regain whilst you consolidate the healthy eating and lifestyle habits you've developed. Maintenance can also involve regular check-ins to monitor your progress and make any necessary adjustments to your treatment plan.
Yes, it may be possible to switch medications, but this should always be discussed with your prescriber first. Different weight loss medications work in different ways. For example, Mounjaro and Wegovy are GLP-1 receptor agonists given by injection, whilst Orlistat works by reducing fat absorption in the digestive system. If you're experiencing troublesome side effects or not seeing the results you'd hoped for, your prescriber can assess whether switching to an alternative medication might be more suitable for you. They'll consider your medical history, the side effects you're experiencing, and your weight loss goals before recommending any changes.
This depends on which medication you're taking. Orlistat can potentially reduce the absorption of oral contraceptives, particularly if you experience diarrhoea, which may make your birth control less effective. If you're taking Orlistat with oral contraceptives, you should use additional barrier contraception (such as condoms) if you have severe diarrhoea lasting more than 12 hours.
Mounjaro and Wegovy may also affect how quickly your stomach empties, which could impact the absorption of oral contraceptives, particularly when you first start treatment or increase your dose. The manufacturers recommend using additional barrier contraception for 4 weeks after starting these medications and for 4 weeks after each dose increase if you're taking oral contraceptives.
Yes, prescription weight loss medications can offer health benefits beyond weight loss itself. Losing weight often leads to improvements in various obesity-related health conditions, and some medications provide additional specific benefits.
GLP-1 receptor agonists (Mounjaro and Wegovy) have been shown to offer several health advantages:
Cardiovascular benefits: Clinical trials have demonstrated that Semaglutide (Wegovy) can reduce the risk of major cardiovascular events such as heart attack and stroke in people with existing heart disease. Tirzepatide (Mounjaro) has also shown promising cardiovascular results.
Blood sugar control: These medications can help improve blood sugar levels and reduce the risk of developing type 2 diabetes, which is why similar formulations are used specifically for diabetes management.
Blood pressure: Many people experience reductions in blood pressure as they lose weight on these medications.
Cholesterol levels: Improvements in cholesterol and triglyceride levels are commonly observed.
Orlistat works differently, by blocking fat absorption, and weight loss achieved with this medication can lead to:
Improved cholesterol levels
Better blood sugar control
Reduced blood pressure
Decreased risk of developing type 2 diabetes
It's important to remember that these additional health benefits are most significant when weight loss medications are combined with sustainable lifestyle changes including a balanced diet and regular physical activity.
Authored on May 12, 2026
Robert Bradshaw (Pharmacist) - MRPharms BSc(Hons) Pharmacy
Superintendent Pharmacist
GPhC Number: 2036118
Reviewed on May 12, 2026
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